PROGRESSIVE SUPRANUCLEAR PALSY – PERK GENE LINKED TO TAU PATHOLOGY
PSP belongs to a group of neurological diseases referred to as “tauopathies.” In these diseases, a molecule called “tau” forms clumping rather than a scaffolding of the cytoskeleton as it normally does. The affected neurons tend to degenerate and even perish. Ordinarily, the prevention of such events undergoes by pathological molecules which are responsible for repairing and disposing by the organism. The protein PERK is part of such a maintenance system. However, in PSP, this mechanism appears to be defective. In previous studies, Höglinger and his colleagues had found that the risk for PSP is associated with variants at the PERK gene level, and that loss of PERK function induced tau pathology in humans.
PROGRESSIVE SUPRANUCLEAR PALSY – PERK GENE LINKED TO TAU PATHOLOGY

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