Gamma-Amino-Butyric Acid

Gamma-Amino-Butyric Acid – GABA has been said by many as being the holy grail of supplements for promoting relaxation and reducing anxiety.

GABA is the ‘downer’ in the world of neurotransmitters, counter-balanced by Glutamate—and all the processes involved.

Many other Nootropics on this list, especially the Racetam family, are thought to act by antagonizing GABA-related receptor sites within the brain, indicating the body’s ability to deeply utilize this Nootropic compound. In addition to it’s neurological benefits, GABA is also taken by many as a way to naturally ‘boost’ Growth Hormone levels. GABA has been shown in clinical trials to increase serum Growth Hormone levels by up to 400%, reaching peak at around 1 hour after ingestion. GABA unfortunately shows great difficulty in it’s ability to cross the blood-brain barrier, making effective dosages somewhat larger compared to other Nootropics on this list. For example, many GABA supplements list a single dosage as being 750mg or more.

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Those seeking GABA as a natural HGH booster often take doses as high as 3-5 grams! While the blood-brain barrier issues causes a bit of difficulty in fully-utilizing GABA supplements, the ‘stacking’ of GABA with a Nitric Oxide-promoting supplement seems to be useful, as Nitric Oxide has been shown to blood-brain permeability of GABA specifically. Many of those taking GABA supplements note that one of the side effects of this supplement is a brief shortness of breath, followed by a ‘pins and needles’ sensation. The shortness of breath—reportedly lasting less than 20 seconds, as well as the ‘pins and needles’ sensation has been reported to occur roughly 60-80 minutes after ingestion of GABA on an empty stomach. While odd perhaps, this side effect isn’t regarded as being serious by most—or even unpleasant—with many of those taking GABA not reporting the issue at all.

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