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Endocannabinoid System

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Endocannabinoid System: What is It?

 

The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. As presented by Mike Membrino, the endocannabinoid system comprises the cannabinoid receptors CB1, CB2 and possibly others; the fatty acid derivatives which act as their endogenous ligands; and the proteins responsible for the synthesis, reuptake and degradation of these endogenous ligands.

Other scientists have discovered the function of this system while examining the role of cannabis. In this case, they presented it with Endo which meant endogenous that originates within the body and cannabinoid refers to a group of compounds that activates the system.

Several researchers have looked at the effects of the endocannabinoid system in the sense that is relates to therapeutic potential in most neurodegenerative disorders.

What are Cannabinoids?

Are commonly referred to as the chemical activators of the endocannabinoid system. In this case, there exist endogenous and exogenous types of cannabinoids. The endogenous as mentioned above originated inside the body system. They are also referred to as the endocannabinoids, these compounds are produced naturally by the human body. They interact with cannabinoid receptors to regulate basic functions including mood, memory, appetite, pain, sleep, and many more.

Exogenous, on the other hand, originating outside the body. CBD as found in hemp is considered exogenous. When consumed, it interacts with cannabinoid receptors to produce physical and psychological effects in the body. Mike Membrino, President of Neuro Endoceutical, USA, suggests a significant difference between THC and CBD showing unlike THC, CBD has little or no affinity for CB1 receptors making it a possible choice for neurological treatments. THC is very psychoactive while CBD is a safe option as they have opposite effects on the body.

What are Cannabinoids receptors?

The endocannabinoid system ECS has two main receptors including CB1 and CB2. CB 1 receptors are expressed in both the central nervous system and periphery. They are the most abundant GPCR in the brain, with high expression levels in the basal ganglia nuclei and moderately high expression in the hippocampus, cerebellum and neocortex (Fine, & Rosenfeld, 2013). Additionally, CB1 are found in the entire part of the body but are mostly present in the brain and spinal cord. They are concentrated in brain regions associated with the behaviors they influence.

On the other hand, CB2 is up-regulated in response to inflammatory cues or immune cell activation. They are found in the peripheral nervous system. They are especially concentrated in immune cells. When CB2 receptors are activated, they work to reduce inflammation. Inflammation is an immune response which is believed to play a role in many diseases and conditions. More recently, CB2 expression has also been reported to occur in normal brain; in neural progenitors (Fine, & Rosenfeld, 2013).

In a general manner, the distribution of CB1 and CB2 receptors in the body suggest their therapeutic benefits when it comes to the treatment of various neurodegenerative disease.

What are endocannabinoids?

Endocannabinoid are produced naturally inside the body. The major components presented by Mike Membrino include 2-AG and anandamide. 2-AG is found at higher concentrations in the brain, while anandamide is found at higher concentrations in other areas of the body. Both are capable of binding to CB1 and CB2 receptors, but differ in their affinities for these receptors.

When endocannabinoids are released in the body, they are broken down by enzymes knowns as fatty acid amide hydrolase and monoacylglycerol lipase.

Functions of Endocannabinoids system

ECS is associated with various function in brain disorders. On the other hand, as presented by Mike Membrino, President of Neuro-Endoceuticals, ECS is involved in regulating various basic functions of the human body. Some of the functions include:

1. Pain management
2. Appetite
3. Mood enhancement
4. Sleep
5. Immune function
6. Inflammatory effects
7. Digestion
8. Cardiovascular function
9. Reproduction
10. Memory and learning
11. Movement
12. Metabolism

Apart from the above-mentioned functions, ECS is involved in treating various mental illnesses. For example, Michael argues that the anandamide and THC are used to lower the blood pressure by triggering the CB1 receptors. In effect, the hypotensive effect is greater in high blood pressure individuals that those with normal blood pressure. This can only suggest that cannabinoids exert stronger effects when a metric is too far from homeostasis. In this case, ECS has high effect on hypertension.

Separately, it is believed that the central objective of CB1 in depression is significantly supported by the effects of traditional antidepressants. Precisely, chronic tricyclic antidepressant treatment increases CB1 density in the hippocampus and hypothalamus, which may mediate the treatment’s therapeutic effects. Increasing anandamide, which enhances activation of CB1 receptors, produces antidepressant-like effects (Smaga, I. et al., 2014). The anti-inflammatory properties of the ECS may also be involved in controlling depression.

There has been anecdotal and preliminary scientific evidence of hemp extract affording symptomatic relief in diverse neurodegenerative disorders. These include multiple sclerosis, Huntington’s, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. This evidence implied that hypofunction or dysregulation of the endocannabinoid system may be responsible for some of the symptomatology of these diseases.

For example, characterization of the CB1 and CB2 receptors are closely linked to the mitigating the underlying biological processes of the Alzheimer’s disease. For instance, Anandamide, function through the activation of the CB1, will tend to stamps down neurotoxicity through various mechanisms. Interestingly, in the process where CB1 reduces and CB2 increases in the brain of the Alzheimer’s disease patients, the endocannabinoids may be produced by neurons and glial cells in response to the beta-amyloid deposition in which they will activate the CB1 neuroprotective pathways and regulate inflammation through CB2,

Similarly, because The ECS is involved in numerous neuro-modulator processes. Pre-clinical educations powerfully suggest that The ECS plays a role in neurogenesis, neurodegenerative procedures, as well as in the neural circuits supposed to be compromised in schizophrenia (Desfosses et al., 2010). In humans, increasing confirmation shows that CB1receptor densities are transformed in schizophrenia and that anandamide levels are preeminent, suggesting that the ECS is involved in the pathophysiology of the disorder.

Other studies show that the ECS is involve in the regulation of homeostasis. According to Mike Membrino, President of Neuro-Endiceuticals, most of the diseases are associated with a LACK of homeostasis. Not surprisingly, the ECS tends to regulate, thereby maintaining at bay and naturally treating various diseases.

Endocannabinoid System as a Medicine

CBD has been the been the most common way of targeting the ECS which tends to stimulate the ECS within the body system and provide the therapeutic impacts. Medical marijuana has been presented with various medical benefits from mood enhancement, appetite, and cognitive function. It can also be used in palliative care to increase the quality of care and promote the wellbeing.

Additionally, there are other synthetic cannabinoids that tend to have a high effect on the ECS. For example, Dronabinol is a synthetic version of THC that is mostly used to prescribe cancer and HIV AIDS patients in combating nausea and appetite. CBD, on the other hand, recent studies have claimed the positive contribution of neuroprotective and anti-inflammatory mechanisms of CBD, suggest that it can be used for therapeutic procedures in dealing with various neurological disorders.

Other clinical studies have recognized the physical effect of hemp extract use, for instance, pain relief, appetite promotion, and inflammation. Additionally, little research or few kinds of literature have been initiated on the efficiency and side effects of CBD in humans. However, most researchers are now describing the impacts of CBD for therapeutic interventions in clinical trials.

In conclusion, regardless of the complexity of the ECS, it is clear that it holds a true value for various scientists and medical professionals.

References
Smaga, I., Bystrowska, B., Gawliński, D., Przegaliński, E., & Filip, M. (2014). The
Endocannabinoid/Endovanilloid System and Depression. Current Neuropharmacology, 12(5), 462–474.
1570159X12666140923205412

Desfossés, J., Stip, E., Bentaleb, L. A., & Potvin, S. (2010). Endocannabinoids and Schizophrenia. Pharmaceuticals, 3(10), 3101–3126.
http://doi.org/10.3390/ph3103101

Scotter, E. L., Abood, M. E., & Glass, M. (2010). The endocannabinoid system as a target for the treatment of neurodegenerative disease. British Journal of Pharmacology, 160(3), 480–498.
5381.2010.00735.x

Fine, P. G., & Rosenfeld, M. J. (2013). The Endocannabinoid System, Cannabinoids, and Pain. Rambam Maimonides Medical Journal, 4(4), e0022.
http://doi.org/10.5041/RMMJ.10129

The History of Plant Based Pain Treatment: Prelude to Cannabidiol – CBD

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Few components like heroin, morphine, oxycodone, methadone, opium, and hydrocodone are derived from a singular plant. i.e.  Poppy plant.

If we look at its history, evidence suggests that this plant was used in South Asian regions. The use of this plant for the treatment of pain goes way back to 3400 B.C. Fast forward, in the early 1900s, studies suggest that opium and heroin have been commonly used for a number of pharmaceuticals preparations mainly for pain relief.

However, with the passage of time, few questions were raised about the addictive nature of this drug. This is the reason why U.S. Congress had to eventually ban its use in major pharmaceuticals. This ban, however, didn’t stop the pharmaceutical companies to pursue further research on this plant and to profit.

They worked religiously to devise ways to look for specific flagrant elements that can be beneficial for opioids. Many scientists found its potential to treat some kind of soreness with this plant based treatment.

 

 

Breakthrough in the early 1900s

Back in 1916, the preparation of a synthetic drug reached its final stages. This drug was termed as oxycodone and it was derived from a poppy plant. It was well received and was later approved by the US in 1939 to be medically used (look how many years it took). Another synthetic drug, Hydrocodone was also extracted from the poppy plant. It was later synthesized in 1920 (so much earlier). These two elements mentioned above were later termed as opioids.

The Purdue Pharma Fraud

One of the companies, Purdue Pharma, formed a long-term type of oxycodone. It was named OxyContin. In 1996, this was drug was marketed at a much higher level. The clinical trials of Oxycontin showed that it may increase addiction. Ignoring this, they lied to the physicians by assuring that this drug is not addictive.

Later in 2007, the company was fined by the FDA for conducting criminal consumer fraud. The company had to pay $634 million for knowingly lying about the addictive potential of Oxycontin. The alarming thing was that damage was already done to a much great level (even to this day) by igniting the opioid epidemic.

Signs of Opioid Abuse

Here are some of the main Signs of Opioid Abuse

  • The state of Euphoria
  • Constipation
  • Drowsiness
  • Loss of consciousness
  • Dramatic Shift in Moods
  • Anxiety, Diarrhea, Headache
  • Insomnia

The treatment should depend on how long you have been using this as well as the last time you took the drug. You need to detox yourself from the drug by slowly getting yourself enrolled in a therapy with the guidance of a physician.

A Final Word

Today, there are 100 million Americans that suffer from chronic pain, more than ever before. The number of addicts and overdose deaths continues to escalate. Till this date, many doctors are of the view that opioids are still the most powerful weapon, especially in case of pain. However, given the scenario mentioned in the article, this drug needs to be checked and banned to avoid any future threat to human life.

References

drugabuse.com/library/opiate-abuse/

familydoctor.org/condition/opioid-addiction/

macllp.com/child-birth-anesthesia/what-are-advantages-and-disadvantages-intravenous-opioids

 

What is CBD / Cannabidiol?

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Cannabidiol – What is it?

There is a thrust for knowledge withing the emergence of extracting CBD and the other Cannabinoids from Hemp plants due its natural element of CBD and lack of THC (though done carefully). Mike Membrino, of Neuro-Endoceuticals asserts that Cannabidiol is one of the most exciting cannabinoids – naturally occurring compound found in Hemp plants – that we are aware of today. Also known as CBD, cannabidiol is transforming from a little-known molecule, to a potential breakthrough nutritional component for treatment of a many disorders under the over-sight of the FDA in clinical trials. This notion is currently preliminary and in the infancy stages of being supported by scientific researchers who are recognizing that taking CBD can be an important option for various neurological illnesses.

Cannabidiol (CBD) is one of the main cannabinoids present in the naturally growing populations and in the industrially cultivated varieties of Hemp Extract. The chemical formula and structure of the CBD element is presented as:

CANNABIDIOL – CBD

The CBD formula is = C21H30O2

According to Borges et al. (2013), CBD is associated with treatment of pain for patients with multiple sclerosis. Contemporary research has discovered that that CBD possesses the following medical properties as presented by Mike Membrino, President of Neuro-Endoceuticals.

Medical Properties of CBD Effects
Anti-oxidant Possibly beneficial in treating neurodegenerative disorders
Anxiolytic/anti-depressant Possibly improves anxiety and depression
Antiemetic Possibily Improves vomiting and nausea
Anticonvulsant Possibily prevents seizures activities
Anti-inflammatory Possibily combats inflammatory disorders
Antipsychotic Possibily combats psychotic disorders
Anti-tumoral/Anti-Cancer Possibily fights tumor cells and cancer cells

 

Cannabidiol (CBD) is found throughout the seeds, stalk and flowers of hemp plants including hemp and hemp extract. Unlike many of the 85+ cannabinoids that we are aware of, cannabidiol occurs naturally in significant quantities in hemp, which makes it the second most abundant cannabinoid in the Hemp plant. As a presented by Mike Membrino, CBD tends to interact with our naturally occurring system and does not have any negative effects like THC that is psychotropically active. In effect, this characteristic makes CBD safer, less controversial alternative, and offers important health benefits.

Just taking CBD is not the answer. It has to be formulated properly with a bio-availability in mind. The delivery is just as important as the product itself. Our CBD is extremely effective since its being delivered to the blood stream.

It’s all in BIOAVALABILITY. Per Mike Membrino, the way to understand this properly is the Human body allows some molecules and substances to enter the blood stream more effectively than others based on certain properties of those respective molecules. Our CBD undergoes ONE extra step of proprietary refining prior to leaving our facilities in order to ensure that we have the BEST CBD in the world. Additionally, our CBD may help with benefiting pain reduction, management of inflammation, and sleeping.

Bioavailability – Wikipedia

In pharmacology, bioavailability (BA) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%. Therefore, with the existing medical hemp market, our CBD have wide arrays of products that can be consumed by various means of administration.

On the other hand, our CBD is characterized by the route of administration that makes it extremely significant to govern the uptake, distribution, and ignition of the body’s own endocannabinoid system. Due to the fact that not all CBD are consumed orally, our CBD have wide arrays in which it can be administered including for oral CBD, oral mucosal CBD through mouth, intranasal, and absorption through the lungs. Soon we will add transdermal as an option.

Finally, Membrino notes that our understanding of CBD hemp oil has expanded and is more interesting in the contemporary medical possibilities of all routes of administartion. In this case, our CBD can be found in liquid and sold form:

  • Capsules
  • Inhalers
  • Syringes
  • Edibles
  • Tinctures
  • Patches (coming soon)

Why use Cannabidiol (CBD) oil Supplements

Various scientific and clinical studies indicate that CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including: rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, antibiotic-resistant infections and neurological disorders. Mike Membrino notes that CBD has demonstrated neuroprotective effects, and its anti-cancer potential is currently being explored at several academic research centers in the U.S. and other countries.

On the other hand, studies have shown that cannabidiol is not psychoactive as compared to THC, which is a well-known high inducing molecule found in a cousin plant known as Marijuana. CBD has no euphoria or sedation since it has no THC. This applies to both humans and animals. Similarly, as argued by Mike Membrino, effects of CBD – rich hemp makes it an appealing treatment option for individuals seeking anti-inflammatory, anxiety and other devastating neurodegenerative diseases.

Separately, CBD has been identified to interact with the body through the endogenous endocannabinnoid system.  In such cases, the ECS has been associated with the regulation of the body’s homestasis or the general state of the balance. Including several nervous functions such as mood, appetite, sleep, hormone regulation, and immune response.

In short, CBD interacts with receptors in the nervous system. Its ability to possibly reduce pain, inflammation, anxiety, and depression. Additionally, cannabidiol (CBD) has been shown by the NIH to have significant antioxidant and neuroprotective properties, suggesting that it could be a potential treatment for neurological disorders as presented in the above table. Additionally, recent studies with synthetic cannabinoids indicate that the activation of CB1 receptors can facilitate neurogenesis including

  • The activation of the TRPV1receptor also known as vanilloid. The receptor controls pain and inflammation sensory organs in the body.
  • Activation of GPR55 receptor also known as a blockade. The receptor controls the sensory organs that fight pain in the body.
  • Finally, it activates the serotonin receptor that helps control stress, anxiety, and mood in the body.

While cannabidiol is not yet FDA approved for any condition, many studies have shown promising results for a variety of indications. Additionally, through anecdotal evidence, many people have used CBD products on their own in an effort to treat various medical issues.

 

Where is CBD found or where does CBD hemp oil Originate?

Cannabidiol is produced in 2 ways:

  1. Naturally, in the hemp plant. Cannabidiol can be found in both hemp and marijuana varieties of cannabis. The main functional difference between hemp and marijuana is the level of THC. Marijuana is grown specifically to contain significant levels of THC – usually for recreational and recently medicinal use, while hemp has only little (<0.3% THC)  or no amounts of THC. CBD found naturally in hemp is also legal on a state level in the United States (like all other hemp products), while CBD from marijuana is federally illegal in the United States, state-by-state legalization is occurring rapidly.
  2. Cannabidiol can also be produced synthetically in a laboratory.

Consequently, growing of hemp for commercial purposes was previously prohibited in the United States, through existing growing domestic demand, it is now legal to grow in a few select states. Importing is still permissible.

Cannabidiol Products and what makes the CBD oil Unique

With the growth in demand for medical marijuana for health reasons, and the legalization movement lagging behind, millions of people are looking for alternative sources of cannabidiol. Because CBD is also a natural ingredient found in hemp, which is legal, the popularity of CBD hemp oil supplements has skyrocketed.

CBD hemp oil products have already been available on the mainstream market for several years now. These include nutritional supplements like daily capsules and drops, gummies, and high concentration extracts. Moreover, CBD hemp oil is a rich nutritional supplement, containing several vitamins and minerals and other healthy constituents. Additionally, CBD is being used to enhance many skin and beauty products, including everything from shampoos to skin creams.

In other words, there exists thousands of unique products of CBD hemp oil supplements. Besides, using the uniquely potent plants, extracting Hemp oil is significant in the sense that it contains higher percentage of CBD together with other essential vitamins, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.

 

How is CBD Hemp Oil Used to Create CBD Products?

After the Hemp plants have been harvested, they go through a specialized solvent-free extraction to yield the CBD hemp oil. The pure extract will then be tested for effective (percentage of CBD and other cannabinoids) and safety (lead, etc).

Finally, as mentioned by Mike Membrino, various bodies follow proper safety protocol to double check for degradation, damage, or contamination in our oil, ensuring one receives only safe, reliable CBD hemp oil products locally grown in the USA.

Our formulators will, therefore, combine the CBD oil with other ingredients to make extensive line-ups for various brands. Then as presented by Mike Membrino, our final CBD hemp oil products are tested for a final time after manufacturing to once again ensure the safety, quality, and cannabinoid content of our products before they are shipped directly to our customers’ doors.

Types of CBD hemp oil products available

Neuro-Endoceuticals offers a variety of CBD hemp oils in various forms. Our CBD can be found in liquid and sold form including Capsules, Applicators, Gummies, and Tinctures.

Pure CBD oils

It the most common potent natural CBD oil available. It is naturally extracted from the hemp plant, tested for use and safety then packaged without additional additives. The product contains a pure and high concentration CBD – generally from 80 to 86%.

CBD tinctures or Liquids

Most of the CBD hemp oil is in liquid form. They are made through mixing of the pure hemp CBD oil into a natural oil base; typically MCT Oil is used. Our products come with great flavors, making them enjoyable to all people.

On the other hand, for those concerned about taste, hemp CBD oil tinctures are a pleasant and convenient way to get your cannabidiol oil nutritional supplement. Tinctures feature sweetened and flavored CBD liquid designed to give you all the natural benefits of cannabidiol while tasting great.

CBD capsules

Due the fact that CBD is associated with vitamin and other important elements, most people like it as CBD oil capsules that everyone can consume in a daily routine.

Additionally, CBD hemp oil capsules offer an incredibly convenient way to get your daily intake of cannabidiol. For those always on the move, CBD hemp oil capsules offer our high-quality cannabidiol hemp oil in a handy, easy-to-swallow pill.

CBD oil tropical, body, and skin care

CBD oil can also be infused into topical and body care products that allow the skin of your body to absorb the cannabidiol oil in the body for its natural benefits. Mike Membrino, argues that Pure CBD hemp oil is naturally an incredible source of vitamins, omega fatty acids, vitamins, terpenes, and chlorophyll, making it a valuable ingredient for radiant and smooth skin.

In conclusion, Mike Membrino, President of Neuro-Endoceuticals notes that CBD oil products hold many benefits as far as positive side effects are concerned. The following are product advantages:

  • CBD can possibly aid to a quick recovery for the body in cases of intense training averting injuries.
  • CBD can possibly help reduce inflammation.
  • CBD can possibly help muscles recover after intense stretch outs.
  • CBD can possibly contribute to improving sleep as the body recuperates quickly during sleep.
  • CBD can possibly help promote one’s appetite. A good feeding habit is indirectly associated with healthy bodies and quick recovery from injuries and ailments.

How to get our CBD oil products

Due to the fact that CBD is derived from a natural plant and 100% legal in all 50 states to use as a dietary supplement throughout. Please click on the products page to purchase CBD.

Please note that this product has not been evaluated by the FDA. CBD is not intended to diagnose, treat, cure, or prevent any disease.

References

Borges et al. (2013). Understanding the Molecular aspect of  THC and CBD anti-oxidants. Journal of Molecules

 

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CBD Oil

Categories: Tags:

Cannabidiol – What is it?

There is a thrust for knowledge withing the emergence of extracting CBD and the other Cannabinoids from Hemp plants due its natural element of CBD and lack of THC (though done carefully). Mike Membrino, of Neuro-Endoceuticals asserts that Cannabidiol is one of the most exciting cannabinoids – naturally occurring compound found in Hemp plants – that we are aware of today. Also known as CBD, cannabidiol is transforming from a little-known molecule, to a potential breakthrough nutritional component for treatment of a many disorders under the over-sight of the FDA in clinical trials. This notion is currently preliminary and in the infancy stages of being supported by scientific researchers who are recognizing that taking CBD can be an important option for various neurological illnesses.

Cannabidiol (CBD) is one of the main cannabinoids present in the naturally growing populations and in the industrially cultivated varieties of Hemp Extract. The chemical formula and structure of the CBD element is presented as:

CANNABIDIOL – CBD

The CBD formula is = C21H30O2

According to Borges et al. (2013), CBD is associated with treatment of pain for patients with multiple sclerosis. Contemporary research has discovered that that CBD possesses the following medical properties as presented by Mike Membrino, President of Neuro-Endoceuticals.

Medical Properties of CBD Effects
Anti-oxidant Possibly beneficial in treating neurodegenerative disorders
Anxiolytic/anti-depressant Possibly improves anxiety and depression
Antiemetic Possibily Improves vomiting and nausea
Anticonvulsant Possibily prevents seizures activities
Anti-inflammatory Possibily combats inflammatory disorders
Antipsychotic Possibily combats psychotic disorders
Anti-tumoral/Anti-Cancer Possibily fights tumor cells and cancer cells

 

Cannabidiol (CBD) is found throughout the seeds, stalk and flowers of hemp plants including hemp and hemp extract. Unlike many of the 85+ cannabinoids that we are aware of, cannabidiol occurs naturally in significant quantities in hemp, which makes it the second most abundant cannabinoid in the Hemp plant. As a presented by Mike Membrino, CBD tends to interact with our naturally occurring system and does not have any negative effects like THC that is psychotropically active. In effect, this characteristic makes CBD safer, less controversial alternative, and offers important health benefits.

Just taking CBD is not the answer. It has to be formulated properly with a bio-availability in mind. The delivery is just as important as the product itself. Our CBD is extremely effective since its being delivered to the blood stream.

It’s all in BIOAVALABILITY. Per Mike Membrino, the way to understand this properly is the Human body allows some molecules and substances to enter the blood stream more effectively than others based on certain properties of those respective molecules. Our CBD undergoes ONE extra step of proprietary refining prior to leaving our facilities in order to ensure that we have the BEST CBD in the world. Additionally, our CBD may help with benefiting pain reduction, management of inflammation, and sleeping.

Bioavailability – Wikipedia

In pharmacology, bioavailability (BA) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%. Therefore, with the existing medical hemp market, our CBD have wide arrays of products that can be consumed by various means of administration.

On the other hand, our CBD is characterized by the route of administration that makes it extremely significant to govern the uptake, distribution, and ignition of the body’s own endocannabinoid system. Due to the fact that not all CBD are consumed orally, our CBD have wide arrays in which it can be administered including for oral CBD, oral mucosal CBD through mouth, intranasal, and absorption through the lungs. Soon we will add transdermal as an option.

Finally, Membrino notes that our understanding of CBD hemp oil has expanded and is more interesting in the contemporary medical possibilities of all routes of administartion. In this case, our CBD can be found in liquid and sold form:

  • Capsules
  • Inhalers
  • Syringes
  • Edibles
  • Tinctures
  • Patches (coming soon)

Why use Cannabidiol (CBD) oil Supplements

Various scientific and clinical studies indicate that CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including: rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, antibiotic-resistant infections and neurological disorders. Mike Membrino notes that CBD has demonstrated neuroprotective effects, and its anti-cancer potential is currently being explored at several academic research centers in the U.S. and other countries.

On the other hand, studies have shown that cannabidiol is not psychoactive as compared to THC, which is a well-known high inducing molecule found in a cousin plant known as Marijuana. CBD has no euphoria or sedation since it has no THC. This applies to both humans and animals. Similarly, as argued by Mike Membrino, effects of CBD – rich hemp makes it an appealing treatment option for individuals seeking anti-inflammatory, anxiety and other devastating neurodegenerative diseases.

Separately, CBD has been identified to interact with the body through the endogenous endocannabinnoid system.  In such cases, the ECS has been associated with the regulation of the body’s homestasis or the general state of the balance. Including several nervous functions such as mood, appetite, sleep, hormone regulation, and immune response.

In short, CBD interacts with receptors in the nervous system. Its ability to possibly reduce pain, inflammation, anxiety, and depression. Additionally, cannabidiol (CBD) has been shown by the NIH to have significant antioxidant and neuroprotective properties, suggesting that it could be a potential treatment for neurological disorders as presented in the above table. Additionally, recent studies with synthetic cannabinoids indicate that the activation of CB1 receptors can facilitate neurogenesis including

  • The activation of the TRPV1receptor also known as vanilloid. The receptor controls pain and inflammation sensory organs in the body.
  • Activation of GPR55 receptor also known as a blockade. The receptor controls the sensory organs that fight pain in the body.
  • Finally, it activates the serotonin receptor that helps control stress, anxiety, and mood in the body.

While cannabidiol is not yet FDA approved for any condition, many studies have shown promising results for a variety of indications. Additionally, through anecdotal evidence, many people have used CBD products on their own in an effort to treat various medical issues.

 

Where is CBD found or where does CBD hemp oil Originate?

Cannabidiol is produced in 2 ways:

  1. Naturally, in the hemp plant. Cannabidiol can be found in both hemp and marijuana varieties of cannabis. The main functional difference between hemp and marijuana is the level of THC. Marijuana is grown specifically to contain significant levels of THC – usually for recreational and recently medicinal use, while hemp has only little (<0.3% THC)  or no amounts of THC. CBD found naturally in hemp is also legal on a state level in the United States (like all other hemp products), while CBD from marijuana is federally illegal in the United States, state-by-state legalization is occurring rapidly.
  2. Cannabidiol can also be produced synthetically in a laboratory.

Consequently, growing of hemp for commercial purposes was previously prohibited in the United States, through existing growing domestic demand, it is now legal to grow in a few select states. Importing is still permissible.

Cannabidiol Products and what makes the CBD oil Unique

With the growth in demand for medical marijuana for health reasons, and the legalization movement lagging behind, millions of people are looking for alternative sources of cannabidiol. Because CBD is also a natural ingredient found in hemp, which is legal, the popularity of CBD hemp oil supplements has skyrocketed.

CBD hemp oil products have already been available on the mainstream market for several years now. These include nutritional supplements like daily capsules and drops, gummies, and high concentration extracts. Moreover, CBD hemp oil is a rich nutritional supplement, containing several vitamins and minerals and other healthy constituents. Additionally, CBD is being used to enhance many skin and beauty products, including everything from shampoos to skin creams.

In other words, there exists thousands of unique products of CBD hemp oil supplements. Besides, using the uniquely potent plants, extracting Hemp oil is significant in the sense that it contains higher percentage of CBD together with other essential vitamins, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.

 

How is CBD Hemp Oil Used to Create CBD Products?

After the Hemp plants have been harvested, they go through a specialized solvent-free extraction to yield the CBD hemp oil. The pure extract will then be tested for effective (percentage of CBD and other cannabinoids) and safety (lead, etc).

Finally, as mentioned by Mike Membrino, various bodies follow proper safety protocol to double check for degradation, damage, or contamination in our oil, ensuring one receives only safe, reliable CBD hemp oil products locally grown in the USA.

Our formulators will, therefore, combine the CBD oil with other ingredients to make extensive line-ups for various brands. Then as presented by Mike Membrino, our final CBD hemp oil products are tested for a final time after manufacturing to once again ensure the safety, quality, and cannabinoid content of our products before they are shipped directly to our customers’ doors.

Types of CBD hemp oil products available

Neuro-Endoceuticals offers a variety of CBD hemp oils in various forms. Our CBD can be found in liquid and sold form including Capsules, Applicators, Gummies, and Tinctures.

Pure CBD oils

It the most common potent natural CBD oil available. It is naturally extracted from the hemp plant, tested for use and safety then packaged without additional additives. The product contains a pure and high concentration CBD – generally from 80 to 86%.

CBD tinctures or Liquids

Most of the CBD hemp oil is in liquid form. They are made through mixing of the pure hemp CBD oil into a natural oil base; typically MCT Oil is used. Our products come with great flavors, making them enjoyable to all people.

On the other hand, for those concerned about taste, hemp CBD oil tinctures are a pleasant and convenient way to get your cannabidiol oil nutritional supplement. Tinctures feature sweetened and flavored CBD liquid designed to give you all the natural benefits of cannabidiol while tasting great.

CBD capsules

Due the fact that CBD is associated with vitamin and other important elements, most people like it as CBD oil capsules that everyone can consume in a daily routine.

Additionally, CBD hemp oil capsules offer an incredibly convenient way to get your daily intake of cannabidiol. For those always on the move, CBD hemp oil capsules offer our high-quality cannabidiol hemp oil in a handy, easy-to-swallow pill.

CBD oil topical, body, and skin care

CBD oil can also be infused into topical and body care products that allow the skin of your body to absorb the cannabidiol oil in the body for its natural benefits. Mike Membrino, argues that Pure CBD hemp oil is naturally an incredible source of vitamins, omega fatty acids, vitamins, terpenes, and chlorophyll, making it a valuable ingredient for radiant and smooth skin.

In conclusion, Mike Membrino, President of Neuro-Endoceuticals notes that CBD oil products hold many benefits as far as positive side effects are concerned. The following are product advantages:

  • CBD can possibly aid to a quick recovery for the body in cases of intense training averting injuries.
  • CBD can possibly help reduce inflammation.
  • CBD can possibly help muscles recover after intense stretch outs.
  • CBD can possibly contribute to improving sleep as the body recuperates quickly during sleep.
  • CBD can possibly help promote one’s appetite. A good feeding habit is indirectly associated with healthy bodies and quick recovery from injuries and ailments.

How to get our CBD oil products

Due to the fact that CBD is derived from a natural plant and 100% legal in all 50 states to use as a dietary supplement throughout. Please click on the products page to purchase CBD.

Please note that this product has not been evaluated by the FDA. CBD is not intended to diagnose, treat, cure, or prevent any disease.

References

Borges et al. (2013). Understanding the Molecular aspect of  THC and CBD anti-oxidants. Journal of Molecules

 

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Plant-based pain treatment: Opioids before Cannabidiol – CBD Oil

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The history of Plant-based Pain treatment: Prelude to Cannabidiol – CBD: The Poppy plant

Few components like heroin, morphine, oxycodone, methadone, opium, and hydrocodone are derived from a singular plant. i.e.  Poppy plant.

If we look at its history, evidence suggests that this plant was used in South Asian regions. The use of this plant for the treatment of pain goes way back to 3400 B.C. Fast forward, in the early 1900s, studies suggest that opium and heroin have been commonly used for a number of pharmaceuticals preparations mainly for pain relief.

However, with the passage of time, few questions were raised about the addictive nature of this drug. This is the reason why U.S. Congress had to eventually ban its use in major pharmaceuticals. This ban, however, didn’t stop the pharmaceutical companies to pursue further research on this plant and to profit.

They worked religiously to devise ways to look for specific flagrant elements that can be beneficial for opioids. Many scientists found its potential to treat some kind of soreness with this plant based treatment.

Breakthrough in the early 1900s

Back in 1916, the preparation of a synthetic drug reached its final stages for treament. This drug was termed as oxycodone and it was derived from a poppy plant. It was well received and was later approved by the US in 1939 to be medically used (look how many years it took). Another synthetic drug, Hydrocodone was also extracted from the poppy plant. It was later synthesized in 1920 (so much earlier). These two elements mentioned above were later termed as opioids.

The Purdue Pharma Fraud

One of the companies, Purdue Pharma, formed a long-term type of oxycodone for treatment. It was named OxyContin. In 1996, this was drug was marketed at a much higher level. The clinical trials of Oxycontin showed that it may increase addiction. Ignoring this, they lied to the physicians by assuring that this drug is not addictive.

Later in 2007, the company was fined by the FDA for conducting criminal consumer fraud. The company had to pay $634 million for knowingly lying about the addictive potential of Oxycontin. The alarming thing was that damage was already done to a much great level (even to this day) by igniting the opioid epidemic.

Signs of Opioid Abuse

Here are some of the main Signs of Opioid Abuse

  • The state of Euphoria
  • Constipation
  • Drowsiness
  • Loss of consciousness
  • Dramatic Shift in Moods
  • Anxiety, Diarrhea, Headache
  • Insomnia

The treatment should depend on how long you have been using this as well as the last time you took the drug. You need to detox yourself from the drug by slowly getting yourself enrolled in a therapy with the guidance of a physician.

A Final Word

Today, there are 100 million Americans that suffer from chronic pain, more than ever before. The number of addicts and overdose deaths continues to escalate. Till this date, many doctors are of the view that opioids are still the most powerful weapon, especially in case of pain. However, given the scenario mentioned in the article, this drug needs to be checked and banned to avoid any future threat to human life.

References

drugabuse.com/library/opiate-abuse/

familydoctor.org/condition/opioid-addiction/

macllp.com/child-birth-anesthesia/what-are-advantages-and-disadvantages-intravenous-opioids

Poppy Plant to Hemp to Cannabidiol

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The history of Plant-based Pain treatment from poppy plant to HempCannabidiolCBD

Opioids are made from two different kinds of elements typically termed as Oxycodone and Hydrocodone. These homegrown poppies can be used to make even a certain tea that is used to treat muscle pain and headaches. On one hand, this drug has few effective properties but on the other hand, its history is quite controversial. This is the reason why many scientists worked on finding other plants that were less addictive. They were quite successful in extracting one from a cannabis plant. This drug was termed as Cannabidiol from the Hemp plant.

The Science of Hemp

With the passage of time, this plant has gained tremendous visibility. The fact is, it is the only known plant to date that contains different anti-psychotic components known as cannabinoids. Research has found out that this component has amazing pain relieving properties.

The human body contains this same component that is termed as endocannabinoids. In case, our body does not help in pain relief then cannabidiol, according to research may possibly be used as an effective alternative to reduce chronic pain. In addition to that, it has also been used to reduce inflammation and anxiety.

Specification of Hemp Plant

Many physicians agree that hemp has a number of medicinal properties, which also includes its ability to relieve pain.

In order to know more, let’s go back in history. The use of typical cannabis plants goes way back in 2700 BC. The hemp plant grows in most parts of the world. However, in the US it has been applied the most for medical purposes till 1941.

After that, the anti-drug crusader along with HenryAnslinger and Rockefeller family banned it with the help of the American Medical Association. This was mainly because their chemical and industrial interests were being threatened by its rising popularity!!!! Surprise surprise.

Cannabidiol as Schedule 1 Drug

The federal government classified hemp as a schedule 1 drug, which is a drug that is considered to have a high abuse potential. This is the reason why it became difficult for researchers to obtain permission in order to further study it. Despite this fact, there has been no report of a casualty from a cannabidiol overdose.

 

What Else?

Furthermore, according to research, CBD may also help to eliminate opioid withdrawal symptoms. Along with that, it also has shown to block the development of tolerating the effects in some opioid users.

A Final Word

The best way Cannabidiol is considered safe for medical purposes is that it does not create physically addictive effects.

It’s a fact that a cannabis plant has been medically used for a long time. Here, an important thing to note is that Cannabidiol still remains illegal at the federal level. However, along with the history of Cannabidiol mentioned above, it can possibly be considered safe when used as an effective medicine for pain relief. This natural and plant based medicine is quickly being shown to improve the quality of life of many individuals with pain.

References

www.deamuseum.org/ccp/opium/history.html

naturalpapa.com/health/opium-poppies-homegrown-pain-medication/

deamuseum.org/ccp/

How can CBD Oil Effect Pain?

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 How can CBD Oil Effect Pain?

CBD oil is one of the main components that is extracted from a hemp plant. Research has proven that it generates positive effects and thus can be helpful to treat different diseases. With the passage of time, it has been used to regulate cardiovascular health as well as certain neuropsychological disorders.

In addition to reportedly reducing anxiety and depression, CBD also helps to eliminate pain to a much great level. Before we jump into further details, let’s discuss the origin of pain. After that, we will proceed on how CBD can help to decrease it.

Pain due to External Factors

When an injury occurs, a nociceptive receptor sends signals of a possible threat to our brain. The feeling of pain emerges when our body responds to any disease or injury. It happens as a result of certain physiological processes that occur within our nociceptive system.

The Science Behind Pain Pathophysiology

Usually, the occurrence of pain is considered as a biologically protective function. A number of pain manifestations may be caused due to tissue injury. It includes hyperalgesia, which is a more exaggerated response to noxious stimulus. Another manifestation is allodynia, which is viewed as pain emerging from typical innocuous stimuli. These two manifestations happen as a result of altercations in central or peripheral nervous system.

Factors that contribute to Sensitization

Sometimes after healing, nociceptive sensory systems start functioning normally.

However, in case our nervous system is disturbed as a result of the injury, then you may expect a chronic neuropathic pain. Therefore, in some people, a certain pain sensitization prevails even after healing. This pain is then accelerated by some permanent structural changes in brain areas that regulate pain. There are certain environmental as well as genetic factors that contribute to this sensitization.

How can CBD oil Help?

Now that we are well aware of pain pathophysiologyphenomenon, we will look at some of the ways Cannabidiol drug can help to relieve acute pain.

According to a review done in 2008, it was proved that CBD oil works instantly to dismiss chronic pain. The biggest benefit of CBD is that it positively interacts with the receptors in our brain. This interaction forms pain-killing effects that reportedly help to elevate pain. In addition to that, consumption of CBD reportedly creates  anti-inflammatory properties, which is especially essential in chronic pain management.

In a Nut Shell

  • It has very less to no side effects.
  • It has been reportedly proven to treat insomnia caused by chronic pain.
  • It has reportedly shown significant potential for pain relief.
  • It does not reportedly have any intoxicating effects.

 What Else?

Arthritis patients may reportedly take a moderate amount of CBD oil for the treatment of recurring pain.

A Final Word

According to research, CBD oil has proven to be quite helpful to provide relief from any kind of pain. Health experts suggest that there is still some research needed in order to be sure about its pain relieving properties. However, keeping in mind CBD’s positive history, we can safely that it can contribute a lot to treat different kinds of pain.

References

healthline.com/health/cbd-oil-for-pain#cancer-treatment

healthyhempoil.com/how-long-does-cbd-take-to-work/

medicalnewstoday.com/articles/319622.php?sr

Cannabidiol – CBD & Stem Cell Interaction

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Cannabidiol – CBD Potentiates Stem Cell Differentiation into Neurons

Stem cells in the body are often characterized by their potential of differentiating into different types of cells as growth occurs. Along with that, stem cells play an important role in our body’s internal repair system. This is the reason why the proliferation of hematopoietic stem cells is quite essential to ensure a strong immune system.

Why is that so?

During their lifetime, our stem cells keep on dividing to reload other cells. This reloading helps to refill all the areas of our body that lack stem cells.

In this article, we will very briefly discuss why the proliferation of hematopoietic stem cells is quite pivotal and how can CBD oil play a major role in this regard.

First, we will have a look at some of the elements that can stimulate hematopoietic cell growth.

5 Essential Elements that Help in the proliferation of hematopoietic stem cells

There is a list of few energy boosting components that help in the proliferation of hematopoietic stem cells. Some of the most important ones are given below:

Vitamin D
There is a fair possibility that promotion and proliferation of hematopoietic stem cells may occur with the use of Vitamin D3, 2000 IU (500% DV). Vitamin D is a steroid hormone that contains aquite broad range of biological effects. These effects range from their role as a mediator of calcium as well as creating phosphate balance that is deemed necessary for cellular differentiation.

L-leucine

Around the world, many scientists have found out that L-leucine is quite effective to boost cognitive thinking. Along with that, it also heals muscle damage due to any external or internal factor.

Blueberry fruit

This is specifically added to decrease some anti-aging properties. It has also been widely used to sustain the health of stem cells. This is the reason why many doctors recommend regular intake of fresh blueberries.

Green tea leaf extract
Green tea leaf extracts mainly act as a required stimulant for skin cell rejuvenation. Many types of research have indicated that it kills cancer stem cells. In addition to that, it also increases our memory. Furthermore, green tea also contains EGCG. It is one of its active ingredients. Most importantly, EGCG has been used to cure a number of medical conditions.

L-carnosine
Although many researchers argue that it does not create any significant change. However, this is quite not the case. Those people who do not eat red meat should take L-carnosine as it can act a good alternative.

What do we know so Far?

The scientific exploration related to stem cell research has sent waves in the field of medicine. In the past, promising new cell technique emerged but these were later eliminated from further research.

What should we Focus on?

In order to ensure the promising proliferation of hematopoietic stem cells, CBD oil can prove to be quite effective. There have been a few studies that concluded that CBD not only regulates proliferation but it also helps in the neurogenesis of mesenchymal stem cells (MCSs).

What About MCSs (Adult Stem Cells)

Due to CBD oil, the adult stem cells were able to depict a higher-level metabolism as well as self-renewal properties. Moreover, they also developed a strong internal immune system and anti-inflammatory properties with the passage of time.

We will further discuss the effects of CBD with the help of different studies that were conducted from 2014-2016.

The Miracles of CBD oil for Proliferation of Hematopoietic Stem Cells

The migration and differentiation of mesenchymal stem cells (MSCs) have been widely utilized to perform various regenerative processes. In order to know whether mobilization occurs as well, certain researches were conducted on CBD oil.

  • Evidence suggested that CBD was able to produce quite a functional effect.
  • It produced long-term stimulation of an induced differentiation of MCSs into a more obsolete lineage. In addition to that, CBD, when combined well with MCSs, helped in sustaining tissue regulation.

Tail Suspension Test

  • Another study on CBD oil conducted that it contains some properties that are similar to that of an anti-depressant. This study is known as ‘tail suspension test’ and it was conducted on non-stressed mice.
  • Furthermore, for the proliferation of hematopoietic stem cells, CBD oil generated dose-dependent effects.
  • Most importantly, another study concluded that when it was given as a regular dose, CBD oil’s administration became independent to the functioning of neurogenesis.

 

What Else?

The Presence of MCSs in Mouth Cavity

During different research, many scientists found out that MCSs are also present in the mouth cavity. The noticeable thing was that some of these cells showed strong properties as compared to other MSCs tissues. This led to the formation of an entirely another experiment. In this experiment, doctors wanted to find out that if oral MCSs became responsive to CBD.

For this purpose, MCSs were collected from five healthy patients and were kept under observation for atleast 24 hours.

Analysis of MCSs

The doctors carefully observed whether the proliferation of hematopoietic stem cells occurred or there was still some need for further research. However, the analysis revealed that when a considerate amount of CBD was given, it significantly created a positive effect on MCSs. Here, an important thing to note is that the quantity given was 5 μM. After increasing the quantity, it was proven that CBD oil might prove to be toxic.

A Final Word

The hematopoietic stem cells are essential for the regeneration of new and healthy stem cells in our body. These cells act as a necessary weapon that stabilizes our immune system. Therefore, it is important to consider all fact and figures mentioned in the article. This knowledge indicates that CBD oil has proven to be quite effective for the rejuvenation and the proliferation of hematopoietic stem cells. However, it is necessary to use moderate quantities to get positive results. It also provides enough evidence that CBD oil has a significant regulatory role when it comes to differentiating stem cells from neurons.

 

References

ncbi.nlm.nih.gov/pmc/articles/PMC3725501/

sciencedaily.com/releases/2012/09/120905083852.htm

sciencedaily.com/releases/2003/04/030425071800.htm

supplementpolice.com/vital-stem/

sciencedirect.com/science/article/pii/S0006295213007478

sciencedirect.com/science/article/pii/S027858461530004X

Warning: Contraindications / Side effects of CBD oil

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Please note this is not an approved list per the FDA or the DEA. CBD remains a schedule 1 drug according to the DEA.

Main Side Effects of CBD Oil

A typical Hemp plant contains two essential elements, mainly known as CBD and THC. These components have the same roots; however, both possess different traits due to which they create entirely different effects on humans.

THC, for example, combines itself with CB1 receptors present in the brain. This collision creates a ‘stoned feeling’ that most people experience when they consume a cannabis plant.

Contrary to this element, CBD interacts quite positively with the CB2 receptor. As a result of this, it does not create a psychoactive effect. As compared to THC, CBD is said to have a neutral effect. This is the reason why CBD oil (extracted from the hemp plant) has been widely recommended for medical use all over the world.

On one side, there are many positive benefits of this component; however, CBD Oil Contraindications cannot be ignored. There are certain potential CBD side effects that you need to be aware of. In this article, we will mainly focus on some of the main CBD oil contraindications.

First, we will discuss some positive traits and then we’ll proceed to the contraindications.

Characteristics of CBD

Research has proven that CBD oil is very beneficial and it is considered as a safe drug for different treatment purposes.

Positive Traits

  • Acts as an Antioxidant
  • Used as an Antiemetic (anti-nausea)
  • Contains Anti-Tumoral Properties (anti-cancer)
  • Works as an Anticonvulsant (anti-vomiting)

What Else?

It is commonly referred by doctors as a natural anti-depressant. Furthermore, CBD is also used as a Neuroprotective agent specifically for stroke treatment (in other words it helps the brain).

What are some of the Possible Risks?

There are no prominent risks involved when it comes to consuming CBD. However, this does not mean that it there are no CBD side effects at all.

One common CBD oil contraindication is a feeling of constant tiredness. In addition to that, there have been reports of some people suffering from diarrhea as well. Moreover, a few people have also observed a significant loss in their weight (sometimes not considered a bad thing by most).

How does CBD effect our endocannabinoid system?

Our endocannabinoid system regulates the body’s homeostasis for a number of adjacent systems. These include mood, anxiety, sleep, appetite as well as the immune system. All these systems face constant fluctuations due to external factors. To solve this problem, the endocannabinoid system creates an equilibrium required by our body.

It is advised to take CBD oil in moderate quantities so that it does not disturb our natural balance.

Be Careful While Consuming

According to an estimate, it is safe to consume CBD oil on a regular basis. However, care is recommended after consulting by a doctor.

Other possible side effects are as follows:

It tends to creates tremor in some Parkinson’s Patients

Some early researchers found out that if CBD is taken in high doses, it might create significant problems for Parkinson’s disease patients. There is a fair possibility that it may affect tremor and muscle movement to a great level.

Some people suggest that if you reduce the intake, it might help to lessen the effects as well. It is better to take necessary guidance from your doctor before beginning your daily dose.

Low blood pressure on a daily basis

If you take more than the required dose of CBD; it might drop your blood pressure to an increasingly low level. Here, the alarming situation is that a reaction like this might occur within minutes after the intake. In such case, you should reduce consuming your blood pressure medications and call 911.

Forms a sense of lightheadedness

The low blood pressure situation mentioned above is sometimes linked to creating a sense of lightheadedness as well. The good news is that this effect is temporary. Most of the times this feeling goes away after you consume a cup of tea or coffee.

Recurring feeling of Drowsiness

No matter for what purpose you are taking CBD, if you are consuming extra quantity or doses, you might suffer from frequent drowsiness. In a situation like this, you should not drive your vehicle or operate any machinery.

It is best to discuss this situation with your doctor. The reason is the same CBD oil can act as a wake-inducing agent if used appropriately.

Dry Mouth even after enough intake of water

After consuming CBD, sometimes the mouth becomes dry and you might feel an unpleasant odor. It happens after the interference of the endocannabinoid system that slows down saliva secretions.

Note:

According to a research conducted in 2006, there are enough cannabinoid receptors that are present in the submandibular glands. The receptors are responsible for creating saliva. After these are activated they modify salivary production, which causes mouth dryness (dry mouth).

Reticence of Metabolism Occurs

Cannabidiol has the tendency to interact with a number of pharmaceuticals. This is due to the fact that it shows some similar qualities as that of a few liver enzymes, commonly known as cytochrome P450. You may also notice decreased activities of p-glycoprotein.

Things to Consider:

This series of pharmaceuticals is typically used to treat humans. In case someone consumes regular doses of CBD, it will neutralize the activity of P450 enzymes even for the time being. This very action is considered as a minor CBD side effect.

In order to resolve this situation, you may eat grapefruits. This action will regulate the metabolism in the body especially for liver enzymes.

What Else?

Some of you might already be taking some effective pharmaceutical drugs. However, if you wish to switch to CBD oil then you should have sound knowledge about all the complexities that come with CBD and must consult with your primary care physician.

A Final Word

Although many studies have indicated that CBD is quite effectual to treat some serious ailments. However, the fact is that only controlled quantities of CBD or other cannabinoids should be given to a patient and only after proper consultation with a doctor.

Furthermore, you should be well aware of all the CBD side effects that are mentioned in the article. This information will help you in making informed decisions.

 

Reference

medicalnewstoday/articles

news.medicalmarijuanainc/cbd-effects-human-body

elixinol/blog/known-and-potential-side-effects-of-cannabidiol-cbd

webmd/vitamins-supplements/ingredientmono-1439-cannabidiol.aspx?activeingredientid=1439&activeingredientname=cannabidiol

CBD & the psychological impact of chronic pain

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Understanding the Psychological Impact of Chronic Pain

At a fundamental level, chronic pain is based on biology: Random nerve impulses continue to alert the brain in regards to the ongoing inflammation and tissue damage leading to the mental component which CBD can possibly assist.

One of the reasons why NeuroEndoceuticals proprietary CBD Oil is so beneficial in combatting Chronic pain is the oil can help combat Negative emotions, including sadness and anxiety.

These emotions seem to aggravate chronic pain even more if not treated. For example, people who dwell on their discomfort tend to be more disabled by chronic pain than people who try to take their pain in stride. And among people with chronic pain stemming from a work-related injury, those who report poor job satisfaction fare worse than those who say they like their jobs.

Keep in mind, our CBD oil is NON-PSYCHOACTIVE – meaning that is does not make you “stoned” or produce a “high” (since its ZERO THC), it indirectly works on the CB1/CB2 receptors which play a part in effecting Anxiety and/or depression. So basically, a side effect of our CBD oil is that it can help reduce anxiety and depression in addition to the natural and organic analgesic effect of pain reduction.

So if CBD doesn’t bind to CB1 and CB2 receptors, how does it all work in simple terms?

CBD does not bind directly to cannabinoid receptors. Instead, CBD works by inhibiting enzyme called FAAH (fatty acid Amide Hydrolase), which is responsible for the breakdown of anandamine – THE most important endocannabinoid in the human and animal body. When FAAH is inhibited, it cannot break down anandamide at its normal rate. This leads to a buildup of anandamide in the brain.

So basically, the CBD oil possesses cannabinoids which bind to an enzyme called FAAH; this in turn stops it from doing its job; which is to “break-down” anandamine. Therefore, levels of anandamine naturally increase which in turn has a cascade effect on the entire endocannabinoid system which ultimately provides an improvement in its efficiency. This improvement in efficiency of the ECS provides a noticeable change in mental well-being as well as body organ system improvements.