Cannabidiol – CBD Potentiates Stem Cell Differentiation into Neurons

Stem cells in the body are often characterized by their potential of differentiating into different types of cells as growth occurs. Along with that, stem cells play an important role in our body’s internal repair system. This is the reason why the proliferation of hematopoietic stem cells is quite essential to ensure a strong immune system.

Why is that so?

During their lifetime, our stem cells keep on dividing to reload other cells. This reloading helps to refill all the areas of our body that lack stem cells.

In this article, we will very briefly discuss why the proliferation of hematopoietic stem cells is quite pivotal and how can CBD oil play a major role in this regard.

First, we will have a look at some of the elements that can stimulate hematopoietic cell growth.

5 Essential Elements that Help in the proliferation of hematopoietic stem cells

There is a list of few energy boosting components that help in the proliferation of hematopoietic stem cells. Some of the most important ones are given below:

Vitamin D
There is a fair possibility that promotion and proliferation of hematopoietic stem cells may occur with the use of Vitamin D3, 2000 IU (500% DV). Vitamin D is a steroid hormone that contains aquite broad range of biological effects. These effects range from their role as a mediator of calcium as well as creating phosphate balance that is deemed necessary for cellular differentiation.

L-leucine

Around the world, many scientists have found out that L-leucine is quite effective to boost cognitive thinking. Along with that, it also heals muscle damage due to any external or internal factor.

Blueberry fruit

This is specifically added to decrease some anti-aging properties. It has also been widely used to sustain the health of stem cells. This is the reason why many doctors recommend regular intake of fresh blueberries.

Green tea leaf extract
Green tea leaf extracts mainly act as a required stimulant for skin cell rejuvenation. Many types of research have indicated that it kills cancer stem cells. In addition to that, it also increases our memory. Furthermore, green tea also contains EGCG. It is one of its active ingredients. Most importantly, EGCG has been used to cure a number of medical conditions.

L-carnosine
Although many researchers argue that it does not create any significant change. However, this is quite not the case. Those people who do not eat red meat should take L-carnosine as it can act a good alternative.

What do we know so Far?

The scientific exploration related to stem cell research has sent waves in the field of medicine. In the past, promising new cell technique emerged but these were later eliminated from further research.

What should we Focus on?

In order to ensure the promising proliferation of hematopoietic stem cells, CBD oil can prove to be quite effective. There have been a few studies that concluded that CBD not only regulates proliferation but it also helps in the neurogenesis of mesenchymal stem cells (MCSs).

What About MCSs (Adult Stem Cells)

Due to CBD oil, the adult stem cells were able to depict a higher-level metabolism as well as self-renewal properties. Moreover, they also developed a strong internal immune system and anti-inflammatory properties with the passage of time.

We will further discuss the effects of CBD with the help of different studies that were conducted from 2014-2016.

The Miracles of CBD oil for Proliferation of Hematopoietic Stem Cells

The migration and differentiation of mesenchymal stem cells (MSCs) have been widely utilized to perform various regenerative processes. In order to know whether mobilization occurs as well, certain researches were conducted on CBD oil.

  • Evidence suggested that CBD was able to produce quite a functional effect.
  • It produced long-term stimulation of an induced differentiation of MCSs into a more obsolete lineage. In addition to that, CBD, when combined well with MCSs, helped in sustaining tissue regulation.

Tail Suspension Test

  • Another study on CBD oil conducted that it contains some properties that are similar to that of an anti-depressant. This study is known as ‘tail suspension test’ and it was conducted on non-stressed mice.
  • Furthermore, for the proliferation of hematopoietic stem cells, CBD oil generated dose-dependent effects.
  • Most importantly, another study concluded that when it was given as a regular dose, CBD oil’s administration became independent to the functioning of neurogenesis.

 

What Else?

The Presence of MCSs in Mouth Cavity

During different research, many scientists found out that MCSs are also present in the mouth cavity. The noticeable thing was that some of these cells showed strong properties as compared to other MSCs tissues. This led to the formation of an entirely another experiment. In this experiment, doctors wanted to find out that if oral MCSs became responsive to CBD.

For this purpose, MCSs were collected from five healthy patients and were kept under observation for atleast 24 hours.

Analysis of MCSs

The doctors carefully observed whether the proliferation of hematopoietic stem cells occurred or there was still some need for further research. However, the analysis revealed that when a considerate amount of CBD was given, it significantly created a positive effect on MCSs. Here, an important thing to note is that the quantity given was 5 μM. After increasing the quantity, it was proven that CBD oil might prove to be toxic.

A Final Word

The hematopoietic stem cells are essential for the regeneration of new and healthy stem cells in our body. These cells act as a necessary weapon that stabilizes our immune system. Therefore, it is important to consider all fact and figures mentioned in the article. This knowledge indicates that CBD oil has proven to be quite effective for the rejuvenation and the proliferation of hematopoietic stem cells. However, it is necessary to use moderate quantities to get positive results. It also provides enough evidence that CBD oil has a significant regulatory role when it comes to differentiating stem cells from neurons.

 

References

ncbi.nlm.nih.gov/pmc/articles/PMC3725501/

sciencedaily.com/releases/2012/09/120905083852.htm

sciencedaily.com/releases/2003/04/030425071800.htm

supplementpolice.com/vital-stem/

sciencedirect.com/science/article/pii/S0006295213007478

sciencedirect.com/science/article/pii/S027858461530004X